Here are the most serious, still-unresolved scientific challenges to the current theories of abiogenesis (as of 2025). These are the issues that keep origin-of-life researchers up at night — not creationist talking points, but real, peer-reviewed problems that the field openly acknowledges. # Problem Why it’s a big deal Current status (2025) 1 Prebiotic synthesis of usable nucleotides RNA-world needs decent yields of the four canonical ribonucleotides (A, G, C, U).